To reach the mission from the north or the south, take Highway 101 to Buellton. Take Exit 140A, for Buellton/Solvang - Highway 246 - and head west (a left turn from the northbound exit, a right turn if southbound).
Proceed west on Highway 246 for approximately 18 miles. On a slight downhill grade you will pass the La Purisima Mission Golf Course on the right. After the golf course, take the second road, which is on the right.
Continue on Purisima Road approximately 1 mile. The mission entrance is on the right.